A Review of Sertraline Loaded Nanocarrier Systems for Enhanced Solubility

Depression is a major global health disorder that significantly affects quality of life and productivity. Sertraline hydrochloride, a widely prescribed selective serotonin reuptake inhibitor, suffers from poor aqueous solubility and pH-dependent precipitation, leading to dissolution-limited absorption and variability in therapeutic response. Conventional formulation approaches such as solid dispersions and inclusion complexes have shown partial improvement but fail to provide consistent and scalable solutions. Nanotechnology-based delivery systems have emerged as promising strategies for addressing such challenges in poorly soluble drugs. Solid lipid nanoparticles (SLNs) are an advanced lipid-based nanocarrier system that combines biocompatibility, structural stability, and controlled drug release properties. The solid lipid matrix enables efficient drug encapsulation, reduces direct drug exposure to aqueous environments, and minimizes precipitation under gastrointestinal conditions. This study proposes the development and optimization of sertraline-loaded SLNs to enhance dissolution behavior and formulation stability. The expected outcomes include improved dissolution performance, reduced precipitation tendency, and enhanced physicochemical stability.